human MCM5 Adenovirus

Name 
Ad-h-MCM5
Cat No 
ADV-215186
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MCM5.

ADV-215186
Ad-h-MCM5

Ready-to-use Adenovirus expressing Human MCM5 (minichromosome maintenance complex component 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CDC46; CDC46 homolog; DNA replication licensing factor MCM5; MCM5 minichromosome maintenance deficient 5, cell division cycle 46; MGORS8; minichromosome maintenance deficient 5 (cell division cycle 46); P1-CDC46
Description (eCommerce)
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM5 can form a subcomplex with MCM3. MCM5 also appears to play a role in transcription. MCM5 has been shown to interact with the signal transducer and activator of transcription 1 (STAT1) and demonstrated to be essential for STAT1 target gene transcription.
Description (Vector)
MCM5 is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
Gene ID
4174
Gene Name (eCommerce)
minichromosome maintenance complex component 5
Gene Name (Vector)
minichromosome maintenance complex component 5
Gene Symbol
MCM5
HGNC ID
HGNC:6948
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2205
ORF Size (bp)
2205 bp
Protein Name (eCommerce)
DNA replication licensing factor MCM5
RefSeq ID
NM_006739
RefSeq Synonyms
NM_006739, BC003656, BC000142,
Research Areas
Cell Cycle,DNA Replication,Helicase Activity,Replication,Signal Transduction,TNF Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
signal_transduction,cell_biology,cell_cycle,genetics,transcription_translation
Species
human
Target Sentence
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM5 can form a subcomplex with MCM3. MCM5 also appears to play a role in transcription. MCM5 has been shown to interact with the signal transducer and activator of transcription 1 (STAT1) and demonstrated to be essential for STAT1 target gene transcription.
UniGene ID
Hs.517582
UniProt ID (eCommerce)
P33992

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.