mouse RFWD3 Over-expression AAV

Name 
AAV-m-RFWD3
Cat No 
AAV-270440
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Rfwd3.

AAV-270440
AAV-m-RFWD3

Ready-to-use AAV expressing Mouse Rfwd3 (ring finger and WD repeat domain 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BC027246
Description (Vector)
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
Gene ID
234736
Gene Name (Vector)
ring finger and WD repeat domain 3
Gene Symbol
Rfwd3
ORF Size (aa)
2325
ORF Size (bp)
2325 bp
RefSeq ID
NM_146218
RefSeq Synonyms
NM_146218, BC096602, BC027246, BC023694, BC018533,
Species
mouse
UniGene ID
Mm.334816

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.