human FMO1 Over-expression AAV

Name 
AAV-h-FMO1
Cat No 
AAV-209180
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human FMO1.

AAV-209180
AAV-h-FMO1

Ready-to-use AAV expressing Human FMO1 (flavin containing monooxygenase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Description (Vector)
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
Gene ID
2326
Gene Name (Vector)
flavin containing monooxygenase 1
Gene Symbol
FMO1
HGNC ID
HGNC:3769
ORF Size (aa)
1599
ORF Size (bp)
1599 bp
RefSeq ID
NM_002021
RefSeq Synonyms
NM_002021, NM_001282694, NM_001282693, NM_001282692, BC047129,
Species
human
UniGene ID
Hs.1424

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.