human FGD1 Over-expression AAV

Name 
AAV-h-FGD1
Cat No 
AAV-208932
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human FGD1.

AAV-208932
AAV-h-FGD1

Ready-to-use AAV expressing Human FGD1 (FYVE, RhoGEF and PH domain containing 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AAS; faciogenital dysplasia 1 protein; FGDY; FYVE, RhoGEF and PH domain-containing protein 1; MRXS16; rho/Rac GEF; rho/Rac guanine nucleotide exchange factor FGD1; ZFYVE3; zinc finger FYVE domain-containing protein 3
Description (eCommerce)
The gene FGD1 encodes for FYVE, RhoGEF and PH domain-containing protein 1. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16 [taken from NCBI Entrez Gene (Gene ID: 2245)].
Description (Vector)
FGD1 encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16.
Gene ID
2245
Gene Name (eCommerce)
FYVE, RhoGEF and PH domain containing 1
Gene Name (Vector)
FYVE, RhoGEF and PH domain containing 1
Gene Symbol
FGD1
HGNC ID
HGNC:3663
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2886
ORF Size (bp)
2886 bp
Protein Name (eCommerce)
FYVE, RhoGEF and PH domain-containing protein 1
RefSeq ID
NM_004463
RefSeq Synonyms
NM_004463, BC034530,
Research Areas
Apoptosis,Cytoskeleton,Golgi Apparatus,GPCR Signaling,Neurobiology,NGF Signaling,Signal Transduction,Zinc-finger
Research Areas (Faceted)
cell_biology,neurobiology,signal_transduction
Species
human
Target Sentence
The gene FGD1 encodes for FYVE, RhoGEF and PH domain-containing protein 1. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs. Defects in this gene are the cause of faciogenital dysplasia and X-linked mental retardation, syndromatic 16 [taken from NCBI Entrez Gene (Gene ID: 2245)].
UniGene ID
Hs.709201
UniProt ID (eCommerce)
P98174

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.