human FBXW11 Over-expression AAV

Name
AAV-h-FBXW11

Cat No
AAV-208830

Availability
4-5 weeks

This is an AAV expressing Human FBXW11.

AAV-208830

AAV-h-FBXW11

Ready-to-use AAV expressing Human FBXW11 (F-box and WD repeat domain containing 11). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BTRC2; BTRCP2; Fbw11; FBW1B; FBXW1B; Hos

Description (Vector)

FBXW11 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. FBXW11 contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.

Gene ID

23291

Gene Name (Vector)

F-box and WD repeat domain containing 11

Gene Symbol

FBXW11

HGNC ID

HGNC:13607

ORF Size (aa)

1590

ORF Size (bp)

1590 bp

RefSeq ID

NM_012300

RefSeq Synonyms

NM_033645, NM_033644, NM_012300, BC026213,

Species

human

UniGene ID

Hs.484138

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.