human EHHADH Over-expression AAV

Name 
AAV-h-EHHADH
Cat No 
AAV-207686
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human EHHADH.

AAV-207686
AAV-h-EHHADH

Ready-to-use AAV expressing Human EHHADH (enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; ECHD; Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase; FRTS3; L-3-hydroxyacyl-CoA dehydrogenase; LBFP; L-bifunctional protein, peroxisomal; LBP; L-PBE; PBE; PBFE; peroxisomal bifunctional enzyme; peroxisomal enoyl-CoA hydratase
Description (eCommerce)
Peroxisomal bifunctional enzyme (PBE) is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of PBE contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in the PBE gene are a cause of peroxisomal disorders such as Zellweger syndrome [taken from NCBI Entrez Gene (Gene ID: 1962)].
Description (Vector)
EHHADH is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1962
Gene Name (eCommerce)
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Gene Name (Vector)
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Gene Symbol
EHHADH
HGNC ID
HGNC:3247
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2172
ORF Size (bp)
2172 bp
Protein Name (eCommerce)
Peroxisomal bifunctional enzyme
RefSeq ID
NM_001966
RefSeq Synonyms
NM_001966, NM_001166415, BC110460, BC038948,
Research Areas
Cytoskeleton,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism
Species
human
Target Sentence
Peroxisomal bifunctional enzyme (PBE) is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of PBE contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in the PBE gene are a cause of peroxisomal disorders such as Zellweger syndrome [taken from NCBI Entrez Gene (Gene ID: 1962)].
UniGene ID
Hs.429879
UniProt ID (eCommerce)
Q08426

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.