Cyclin D1

Product Category: human Adenovirus Type5 (dE1/E3)

Gene Name: Cyclin D1

Gene Alias: BCL1, CCND1, PRAD1, U21B31, D11S287E, Cyclin D1

GeneBank Number: BC000076

Description:

Cyclin dependent kinases (Cdks) are critical regulators of cell cycle progression that are constitutively expressed throughout the cell cycle. Family members include Cdc2 p34, Cdk2-9, PITSLRE, PCTAIRE-1-3, KKIAMRE, KKIALRE and NKIAMRE. Prototype members of this family include Cdc2 p34 and Cdk2, which function late in the cell cycle, whereas other members, Cdk4, Cdk6 and a related protein Cdc7, are critically involved in the G1 and S phase transitions. Cdks comprise the catalytic subunit of the cell cycle kinases and they associate with specific regulatory subunits to form an active complex. Cyclin H is one such regulatory subunit that preferentially binds to Cdk7 and forms the cyclin H/Cdk7 complex, which then phosphorylates Cdc2, Cdk2 and Cdk4 to regulate cell cycle progression. Cyclin D1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

References:

• Pkcalpha Tumor Suppression In The Intestine Is Associated With Transcriptional And Translational Inhibition Of Cyclin D1.
  Exp Cell Res. 2009. 315(8):1415-28

Cat. No.	Tag	Promoter		Species	Price **	Availability
1517		CMV		human	$445.00	In Stock

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