Glycogen synthase kinase 3 alpha adenovirus
Product Name: Ad-GSK3A
Product Category: Ready-use human Adenovirus Type5 (dE1/E3)
Gene Name: GSK3A
Gene Alias: GSK3A
GeneBank Number: BC027984
Description: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine, proline directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion and is implicated in Alzheimer's disease. Two forms of GSK-3, designated GSK-3(alpha) and GSK-3(beta), are related yet they differ in their subcellular localization. The microtubule binding protein, Tau, serves to stabilize microtubules in growing axons. Tau is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3, presenting the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer's disease.
Titer: 1x1010 PFU/ml
Volume: 200ul
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
Availability: In stock, same day shipping available for orders placed before 1PM.
| Catalog No. |
Tag |
Promoter |
|
Species |
Price ** |
 |
| 1424 |
|
CMV |
|
human |
$690.00 |
|
