Cyclin-dependent kinase 5, regulatory subunit 1 (p35) adenovirus

Product Category: Ready-use human Adenovirus Type5 (dE1/E3)

Gene Name: p35

Gene Alias: P23,P25,P35,CDK5R,NCK5A,CDK5R1,CDK5P35,MGC33831,P35NCK5A

GeneBank Number: BC020580

Description:

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

Availability: In stock, same day shipping available for orders placed before 1PM.

References:

• Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
  Cell Death Dis. . 2011. 2(2):120

Catalog No.	Tag	Promoter		Species	Price **
1385		CMV		human	$475.00

• ** Price for US/Canada customers only.
  International price may vary. For more Product Ordering and Shipping information, please click here