IKKα adenovirus
Product Name: Ad-CMV-IKKα
Product Category: Ready-use human Adenovirus Type5 (dE1/E3)
Description: IKKα
The transcription factor NFκB is retained in the cytoplasm in an
inactive form by the inhibitory protein IκB. Activation of NFκB
requires that IκB be phosphorylated on specific serines residues,
which results in targeted degradation of IκB. IκB
kinase α (IKKα), previously designated CHUK, interacts with
IκB-α and specifically phosphorylates IκB-α on the sites that
trigger its degradation, serines 32 and 36. IKKα appears to be
critical for NFκB activation in response to proinflammatory
cytokines. Phosphorylation of IκB by IKKα is stimulated by
the NFκB inducing kinase (NIK), which itself is a central
regulator for NFκB activation in response to TNF and IL-1.
The functional IKK complex contains three subunits, IKKα , IKKβ
and IKKγ (also designated NEMO), and each appear to make
essential contributions to IκB phosphorylation.
Titer: 1x1010 PFU/ml
Volume: 200ul
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
Availability: In stock, same day shipping available for orders placed before 1PM.
| Catalog No. |
Tag |
Promoter |
|
Species |
Price ** |
 |
| 1181 |
|
CMV |
|
|
$475.00 |
|
