p53

Product Category: human Adenovirus Type5 (dE1/E3)

Description:

The widely studied p53 tumor suppressor gene contains mutations in over 50% of human cancers. p53 protein expression is low in normal cells but increases in response to DNA damage and cellular distress signals. Overexpression of the p53 transcription factor can induce either cell cycle arrest or apoptosis through transcriptional regulation of several genes, including the cell cycle inhibitor p21, DNA repair gene GADD45 and the apoptotic inducer Bax. p53 also induces apoptosis by means of a direct signaling pathway involving the expression of p53AIP1. p53 directly binds to and acts on several cellular proteins involved in various pathways, including c-Abl, basal transcription factor TFIIH and WT1. p53 can be functionally inactivated by mutation, binding to DNA tumor virus encoded proteins, such as SV40 large T antigen, Adenovirus E1B and papilloma virus E6 proteins, or through its interaction with MDM2.

Reference: Polyak K., et al., Genes Dev. 1996 Aug 1;10(15):1945-52.

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

References:

• Apoptosis Inhibition by the Human DEK Oncoprotein Involves Interference with p53 Functions
  Molecular and Cellular Biology. 2006. 26(20):7506-7519

Cat. No.	Tag	Promoter		Species	Price **	Availability
1168		CMV		Human	$445.00	In Stock

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