Rb
Product Name: Ad-CMV-Rb
Product Category: human Adenovirus Type5 (dE1/E3)
Description: The retinoblastoma susceptibility protein Rb is a 110 kDa phosphorylated protein. Like p53, Rb p110 is an anti-oncogene that is subject to inactivation by either mutation or by binding to certain DNA tumor virus-encoded proteins. Rb binds to and regulates transcription factors involved in cell cycle regulation, including the E2F family. Two Rb related proteins, p107 and p130, also function to regulate specific members of the E2F transcription factor family. Binding and inactivation of E2F proteins by Rb is regulated by cyclin dependent kinase-mediated phosphorylation
Titer: 1x1010 PFU/ml
Volume: 200ul
Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol
References: - Proto-Oncogene Fbi-1 (Pokemon/Zbtb7a) Represses Transcription Of The Tumor Suppressor Rb Gene Via Binding Competition With Sp1 And Recruitment Of Co-Repressors.
J. Biol. Chem. 2008. 283(48):33199-210. - Rb Depletion Results In Deregulation Of E-Cadherin And Induction Of Cellular Phenotypic Changes That Are Characteristic Of The Epithelial-To-Mesenchymal Transition
Cancer Research. 2008. 68:5104-5112
| Cat. No. |
Tag |
Promoter |
|
Species |
Price ** |
Availability |
 |
| 1043 |
|
CMV |
|
Human |
$445.00 |
In Stock |
|
