Ras (N17) adenovirus

Product Category: Ready-use human Adenovirus Type5 (dE1/E3)

Description:

Ras genes encode 21 kDa guanine nucleotide-binding proteins, including H-, K- and N-Ras. H-Ras was first identified as oncogene, mutated Ras genes have been found in many human tumors. Like all GTPases, Ras act as molecular switch to control downstream cellular events. The interconversion of the inactive GDP-bound form into the active GTP-bound form is regulated by guanine nucleotide exchange factors, whereas inactivation of the GTP-bound form is stimulated by GTPase-activating proteins (GAPs). Ras in its active GTP bound form binds to Raf, resulting in activation of MAP kinase cascade. The provided recombinant adenovirus contains dominant negative form of human H-Ras (T17N).

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

Availability: In stock, same day shipping available for orders placed before 1PM.

References:

• Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-alpha expression and improves cardiac function during endotoxemia.
  Cardiovasc Research. 2011. :doi: 10.1093/cvr/cvr346

• Hiv-1 Tat Activates Dual Nox Pathways Leading To Independent Activation Of Erk And Jnk Map Kinases
  J. Biol. Chem.. 2007. 282(52):37412-37419

Catalog No.	Tag	Promoter		Species	Price **
1031		CMV	dominant negative		$475.00

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